Antibacterial, Antiviral, Antioxidant Activity and Chemical Content of Propolis

Authors

  • Pınar COŞKUN Bingöl Üniversitesi, Fen Bilimleri Enstitüsü
  • Hakan İNCİ Bingöl Üniversitesi Ziraat Fakültesi Zootekni Bölümü

DOI:

https://doi.org/10.46291/ISPECJASvol4iss4pp1051-1068

Keywords:

Propolis, apitherapy, antioxidant, antiviral, antimicrobial

Abstract

Propolis is a natural resinous mixture produced by honey bees from substances collected from some parts of plants, buds and secretions. Propolis is one of the few "natural remedies" used since ancient times. More than 300 active compounds have been identified in propolis, such as phenolic compounds, aromatic acids, essential oils, waxes and amino acids. Thanks to its antioxidant, antibacterial and antiviral effects, propolis has been shown to have various health benefits on some diseases. Propolis is a natural bee product that is used as a multi-functional in medicine, cosmetics, food industry and apitherapy, in addition to being used by bees in the hive due to its antibacterial and antioxidant properties. In this study, the biological and healing properties of propolis were tried to be emphasized, and some of the studies on human health effects were given under certain headings.

References

Ackermann, T. 1991. Fast chromatography study of propolis crudes. Food Chemistry, 42: 135-138.

Ahuja, V., Ahuja, A. 2011. Apitherapy-a sweet approach to dental diseases. Part II:

propolis. J. Adv. Oral Res. 2: 1–8.

Alcıcı, NMF. 1996. Heavy metals in propolis: practical and simple procedures to

reduce the lead in the Brazilian propolis. Chemical Abstracts, 127: 236-247.

Almeıda EC., Menezes H. 2002. Anti-inflammatory activity of propolis extracts: A Review. J. Venom. Anim. Toxins, 8: 191-212.

Al-Waili, N., Al-Ghamdi, A., Ansari, MJ., Al-Attal, Y., Salom, K. 2012. Synergistic effects of honey and propolis toward drug multi-resistant Staphylococcus aureus, Escherichia coli and Candida albicans isolates in single and polymicrobial cultures. Int. J. Med. Sci. 9,

Amoros, M., Sauvager, F., Girre, L., Cormier, M. 1992a. In vitro antiviral activity of propolis. Apidologie 23: 231–240.

Amoros, M., Simõs, C., Girre, L., Sauvager, F., Cormier, M. 1992b. Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis. J. Nat. Prod. 55: 1732–1740.

Anjum, SI., Ullah, Khan, KA., Attaullah, M., Khan, H., Ali, H., Bashir MA., Tahir M., Ansari MJ., Ghramh, HA., Adgaba N, Dash, CK. 2019. Composition and functional properties of propolis (bee glue): A review. Saudi Journal of Biological Sciences 26: 1695–1703.

Anonim,2020.https://avys.omu.edu.tr/storage/app/public/aguler/66940/ARI%20YET%C4%B0%C5%9ET%C4%B0R%C4%B0C%C4%B0L%C4%B0%C4%9E%C4%B0.pdf.

Bankova, V. 2005. Chemical diversity of propolis and the problem of standardization.

J. Ethnopharmacol. 100: 114-7.

Bankova, VS., De Castro, SL., Marcucci, MC. 2000. Propolis: recent advances in chemistry and plant origin, Apidologie, 31(1): 3–15.

Bankova, VS., Castro, DSL., Marcucci, MC. 2000. Propolis: Recent advances in chemistry and plant origin. Apidologie, 31: 3–15.

Bankova, VS., Popov, SS., Marekov, NL. 1989. Isopentenyl cinnamates from poplar buds and propolis. Phytochemistry, 28: 871-3.

Blonska, M., Bronikowska, J., Pietsz, G., Czuba, ZP., Scheller, S., Krol, W. 2004. Effects of ethanol extract of propolis (EEP) and its flavones on inducible gene expression in J774A.1 macrophages, Journal of Ethnopharmacology, 91(1): 25–30.

Bogdanov, S. 2012. Propolis: Composition, Health, Medicine: A Review. Bee Product Science, www.bee-hexagon.net Castaldo, S., Capasso, F. 2002. Propolis, an old remedy used in modern medicine. Fitoterapia, 73: 1-6.

Castaldo, S., Capasso, F. 2002. Propolis, an old remedy used in modern medicine.

Fitoterapia 73:1–6.

De Castro, S. 2001. Propolis: biological and pharmacological activities. Therapeutic uses of this bee-product. Ann. Rev. Biomed. Sci. 3: 49–83.

Dıaz JCQ., Rodrígues OA., Velázquez MD., Mılıá NML. 1997. Empleo de la tintura de propóleo en la cura de heridas sépticas faciales. Rev. Cuba Estomatol. 34: 347-51.

Dıaz, NJ., Quevedo, AO., Luna, SB. 1997. Determination of Fe, Mn, Zn, and Cu in an ethanolic extract of Cuban propolis. Rev. CENIC. Ciências Químicas, 28: 93-5.

El Hady, FKA., Hegazi, AG. 2002. Egyptian propolis: 2. Chemical composition, antiviral and antimicrobial activities of East Nile Delta propolis. Zeitschrift für Naturforschung C 57: 386–394.

Fernandes, JA., Sugızakı, MF., Fogo, ML., Funare, SRC., Lopes, CAM. 1995. In

vitro activity of propolis against bacterial and yeast pathogens isolated from human infections. J. Venom. Anim. Toxins, 1: 63-9.

Fokt, H., Pereira, A., Ferreira, A., Cunha, A., Aguiar, C. 2010. How do bees prevent

hive infections? The antimicrobial properties of propolis. Curr. Res. Technol. Educ. Top. Appl. Microbiol. Microbial. Biotechnol. 1: 481–493.

Fri´on-Herrera, Y., D´ıaz-Garc´ıa, A., Ruiz-Fuentes, J., Rodr´ıguez-S´anchez, H., Sforcin, J. M. 2015. Brazilian green propolis induced apoptosis in human lung cancer A549 cells through mitochondrial-mediated pathway,” Journal of Pharmacy and Pharmacology, 67(10): 1448–1456.

Ghısalbertı EL. 1979. Propolis: a review. Bee World, 60, 59-84.

Goik, U., Ptaszek, A., Goik, T. 2015. The influence of propolis on rheological properties of lipstick, International Journal of Cosmetic Science, 37(4): 417–424.

Grange, J., Davey, R. 1990. Antibacterial properties of propolis (bee glue). J. R. Soc. Med. 83: 159–160.

Grange, J., Davey, R. 1990. Antibacterial properties of propolis (bee glue). J. R. Soc. Med. 83: 159–160.

Harfouch, R.M., Mohammad, R., Suliman, H. 2016. Antibacterial activity of syrian propolis extract against several strains of bacteria in vitro.

Hausen, BM., Wollenweber, E., Senff, H., Post, B. 1987. Propolis allergy: (I). Origin, properties, usage and literature review, Contact Dermatitis, 17(3):163–170.

Havsteen, BH., 2002. The biochemistry and medical significance of the flavonoids.

Pharmacol. Therapeutics, 96: 67-202.

Helfenberg, KD. 1908. The analysis of beeswax and propolis, Chemiker Zeitungm, 31:987–998.

Hwu YJ., Lin, FY. 2014. Effectiveness of propolis on oral health: a meta-analysis, Journal of Nursing Research, 22(4): 221–229.

Hwu, YJ., Lin, FY. 2014. Effectiveness of propolis on oral health: a meta-analysis, Journal of Nursing Research, 22(4): 221–229.

Kasiotis, K.M., Anastasiadou, P., Papadopoulos, A., Machera, K. 2017. Revisiting Greek Propolis: chromatographic Analysis and Antioxidant Activity Study. PLoS ONE 12, e0170077.

Kedzia, B. 2006. Skład chemiczny i aktywnos´c´ biologiczna propolisu pochodza˛cego z róz˙nych rejonów s´wiata. Post. Fitoter, 1: 23–35.

Kedzia, B. 2008. Pochodzenie propolisu w ´swietle teorii i bada´n naukowych. The

origin of propolis in the theories and scientific research. Herba Pol. 54: 179–186.

Kedzia, B., Hołderna-Kedzia, E. 2017. Pinocembrin—flavonoid component of domestic propolis with delaying e_ect of the development of Alzheimer’s disease. Post.

Fitoter. 18: 223–228.

Kovalik, PV. 1979. The use of propolis in the treatment of patients with chronic fungal sinusitis. Vestnik otorindaringologii No.6, 60-62.

Kujumgiev, A., Tsvetkova, I., Serkedjieva, Y., Bankova, V., Christov, R., Popov, S. 1999. Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. J. Ethnopharmacol. 64: 235–240.

Kumazawa, S., Hamasaka, T., Nakayama, T., 2004. Antioxidant activity of propolis of various geographic origins. Food Chemistry, 84: 329-39.

Kuropatnicki, A.K., Szliszka, E., Krol, W. 2013. Historical aspects of propolis research in modern times. Evidence-Based Complement. Alternat. Med.

Li, N., Li, YQ., Li, HY., Guo, W., Bai, YP. 2012. Efficacy of externally applied chinese herbal drugs in treating psoriasis: a systematic review, Chinese Journal of Integrative Medicine, 18(3): 222–229.

Lotfy, M. 2006. Biological activity of bee propolis in health and disease. Asian Pac. J. Cancer Prev. 7: 22–31.

Machado, B., Pulcino, T.N., Silva, A.L., Tadeu, D., Melo, R.G.S., Mendonça, I.G. 2017. Propolis as an alternative in prevention and control of dental cavity. Immunity 19, 24.

Mani, R., Natesan, V., 2018. Chrysin: Sources, beneficial pharmacological activities,

and molecularmechanism of action. Phytochemistry, 145:187-196.

Marcuccı MC., Rodrıguez J., Ferrerez F., Bankova V., Grotor., Popov S. 1998. Chemical composition of Brazilian propolis from São Paulo State. Z. Neturforsch. Sect. C. Biosc., 53: 117-9.

Marcuccı, MC. 1995. Propolis: Chemical composition, biological properties and therapeutic activity. Apidologie, 26: 83-99.

Martin, M.P., Pileggi, R. 2004. A quantitative analysis of Propolis: a promising new storage media following avulsion. Dent. Traumatol. 20: 85–89.

Martinotti, S., Ranzato, E. 2015. Propolis: a new frontier for wound healing? Burns Trauma 3, 9.

Menezes, H. 2005. Própolis: uma revisão dos recentes estudos de suas propriedades farmacológicas. Arq. Inst. Biol., 72: 405-11.

Monti, M., Berti, E., Carminati, G., Cusini, M. 1983. Occupational and cosmetic dermatitis frompropolis, ContactDermatitis, 9(2): 163.

Mousavi, M., Mannani, R., Mottaghi, M., Torkan, B., Afrouzan, H. 2016. Comparing the effect of propolis vaginal cream and metronidazol vaginal gel for treatment of bacterial vaginosis, Journal of Zanjan University of Medical Sciences and Health Services, 24(106): 42–50.

Nabavi, SF., Braidy, N., Habtemariam, S., Orhan, IE., Daglia, V., Manayi, A., Gortzi, O., Nabavi, SM. 2015. Neuroprotective effects of chrysin: From chemistry to medicine. Neurochemistry International 90: 224-231.

NievaMoreno, MI., Isla, MI., Sampieto, AR., Vattuone, MA. 2000. Comparison of the free radical-scavenging activity of propolis from several regions of Argentina. Journal of Ethnopharmacology,71: 109–114.

Park, YK., Ikegakı, M., Abreu, JA., Alcıcı, NM. 1998. Estudo da preparação dos extratos de própolis e suas aplicações. Ci. Tecnol. Aliment, 18: 313-8.

Parolia, A., Thomas, M.S., Kundabala, M., Mohan, M. 2010. Propolis and its potential uses in oral health. Int. J. Med. Med. Sci. 2: 210–215.

Pasupuleti, VR., Sammugam, L., Ramesh, N., Gan, SH. 2017. Honey, propolis and royal jelly: A comprehensive review of their biological actions and health benefits. Oxid. Med. Cell Longev. 2017, 1259510.

Pillai, SI., Palsamy, P., Subramanian, S., Kandaswamy, M. 2010. Wound healing properties of Indian propolis studied on excision wound-induced rats, Pharmaceutical Biology, 48(11): 1198–1206.

Pimenta, H.C., Violante, I.M., Musis, C.R., Borges, Á.H., Aranha, A.M. 2015. In

vitro e_ectiveness of Brazilian brown propolis against Enterococcus faecalis. Braz. Oral Res. 29: 1–6.

Przybyłek I., Karpinski, TM. 2019. Antibacterial Properties of Propolis. Department of Medical Microbiology, Pozna´n University of Medical Sciences, Wieniawskiego 3, 61-712 Pozna´ n.

Ramos AFN., Mıranda JL. 2007. Propolıs: A Revıew Of Its Antı-Inflammatory and Healıng Actıons. J. Venom. Anim. Toxins İncl. Trop. Dis. 13(4): 697-710.

Russo, A., Cardile, V., Sanchez, F., Troncoso, N., Vanella, A., Garbarino, JA. 2004. Chilean propolis: antioxidant activity and antiproliferative action in human tumor cell lines. In Life Sciences 76 (5): 545–558.

Salatıno, A., Teıxeıra, EW., Negrı, G., Message, D. 2005. Origin and chemical variation of Brazilian propolis. Evid. Based Complement. Alternat. Med., 2: 33-8.

Santos, VR., Pereira, EMR., Da Silva JLDC. 2011. “Clinical evidence of the efficacy of a mouthwash containing propolis for the control of plaque and gingivitis: a phase II study,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 750249, 7 pages.

Savka, MA., Dailey, L., Popova M. 2015. Chemical composition and disruption of quorum sensing signaling in geographically diverse United States propolis,” Evidence-Based Complementary and AlternativeMedicine, vol. 2015, Article ID 472593, 10 pages.

Senedese, JM., Rodrigues, AR., Furtado MA. 2011.Assessment of the mutagenic activity of extracts of Brazilian propolis in topical pharmaceutical formulations on mammalian cells in vitro and in vivo, Evidence-based Complementary and Alternative Medicine, vol. 2011, Article ID 315701, 7 pages.

Sforcin, J., Fernandes, A., Lopes, C., Bankova, V., Funari, S. 2000. Seasonal effect on Brazilian propolis antibacterial activity. J. Ethnopharmacol. 73: 243–249.

Sforcin, J.M. 2016. Biological properties and therapeutic applications of propolis. Phytother. Res. 30: 894–905.

Silici, S., Kutluca, S. 2005. Chemical composition and antibacterial activity of propolis collected by three different races of honeybees in the same region. J. Ethnopharmacol., 99: 69-73.

Sung, SH., Choi, GH., Lee, NW., Shin, BC. 2017. External Use of Propolis for Oral, Skin, and Genital Diseases: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. Volume 2017, Article ID 8025752, 10 pages

Szliszka, E., Krol, W. 2013. Polyphenols isolated from propolis augment TRAIL- induced apoptosis in cancer cells, Evidencebased Complementary and Alternative Medicine, vol. 2013, Article ID 731940, 10 pages.

Teıxeıra, EW., Negrı, G., Meıra, RM., Message, D., Salatıno, A. 2005. Plant origin

of green propolis: Bee behavior, plant anatomy and chemistry. Evid. Based Complement. Alternat. Med., 2: 85-92.

Tosı, B., Donını, A., Romagnolı C., Brunı, A. 1996. Antimicrobial activity of some commercial extracts of propolis prepared with different solvents. Phytother. Res., 1014, 335-6.

Tosi, B., Donini, A., Romagnoli, C., Bruni, A. 1996. Antimicrobial activity of some Commercial Extracts of Propolis Prepared with different solvents. Phytother. Res. 10:335–336.

Trusheva, B., Popova, M., Bankova, V. 2006. Bioactive constituents of Brazilian red propolis, Evidence-based Complementary and Alternative Medicine, 3(2): 249–254.

Uzel, A., Önçag˘, Ö., Çog˘ulu, D., Gençay, Ö. 2005. Chemical compositions and antimicrobial activities of four different Anatolian propolis samples. Microbiol. Res. 160: 189–195.

Vynograd, N., Vynograd, I., Sosnowski, Z. 2000. A comparative multi-centre study

of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes (HSV), Phytomedicine, 7(1): 1–6.

Wagh, VD. 2013. Propolis: A Wonder Bees Product and Its Pharmacological Potentials. Review. Wollenweber, E., Hausen, BM., Greenaway, W. 1990. Phenolic constituents and sensitizing properties of propolis, poplar balsam and balsam of Peru,” Bulletin de Liaison—Groupe Polyphenols, 15: 112–120.

Zabaiou, N., Fouache, A., Trousson, A. 2017. Baron, S., Zellagui, A., Lahouel, M.,

Lobaccaro, J.A. Biological properties of propolis extracts: Something new from an ancient product. Chem. Phys. Lipids, 207, 214–222.

Published

2020-12-04

How to Cite

Pınar COŞKUN, & Hakan İNCİ. (2020). Antibacterial, Antiviral, Antioxidant Activity and Chemical Content of Propolis. ISPEC Journal of Agricultural Sciences, 4(4), 1053-1070. https://doi.org/10.46291/ISPECJASvol4iss4pp1051-1068

Issue

Section

Review