Analysis Of The Influence Of Alcohol-Induced Stress On The Quantitative And Qualitative Composition Of Amino Acids Related To S-Adenosylmethionine And Glutathione Transformations


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Authors

  • Petro Fedyshyn National University of Life and Environmental Sciences of Ukraine, Department of Biochemistry and Physiology of Animals named after Academician M.F. Gulyi
  • Oleh Smirnov Laboratory of Molecular Biology and Clinical Biochemistry, Institute of Animal Biology NAAS, V. Stusa, 38, Lviv, 79034, Ukraine
  • Liliia Kalachniuk National University of Life and Environmental Sciences of Ukraine, Department of Biochemistry and Physiology of Animals named after Academician M.F. Gulyi

DOI:

https://doi.org/10.46291/ISPECJASvol5iss4pp977-983

Keywords:

alcohol-induced oxidative stress, Amino acids, S-adenosylmethionine, Glutathione, Bioprotectors, Rats.

Abstract

Studies of preparations that decrease oxidative stress and, as a consequence, that can prevent or reduce the development of alcoholic liver disease are relevant. A wide range of drugs, the bioprotective effect of which is studied, in its action is associated with natural antioxidant systems. Therefore, the study of the features of these systems is necessary for the effective development of bio protectors. The aim is to analyze changes in the quantitative and qualitative composition of amino acids involved in antioxidant mechanisms in the presence of alcohol-induced stress in rats. In the presence of alcohol-induced oxidative stress, there are changes in the quantitative and qualitative composition of amino acids (methionine, serine, taurine), which are involved in the mechanisms of antioxidant protection - cycles of S-adenosylmethionine and glutathione. A slight increase in methionine levels in the blood serum of animals of the experimental group and disruption of the recovery cycle of methionine under alcohol-induced oxidative stress are arguments for the ineffectiveness of S-adenosylmethionine as a bioprotective substance. The same decrease in the level of serine (by 15%) and taurine (by 13%), and analysis of literature data, may be indicate the "secondary" nature of glutathione as an antioxidant compared to taurine.

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Published

2021-12-12

How to Cite

Petro Fedyshyn, Oleh Smirnov, & Liliia Kalachniuk. (2021). Analysis Of The Influence Of Alcohol-Induced Stress On The Quantitative And Qualitative Composition Of Amino Acids Related To S-Adenosylmethionine And Glutathione Transformations. ISPEC Journal of Agricultural Sciences, 5(4), 977–983. https://doi.org/10.46291/ISPECJASvol5iss4pp977-983

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