1
Ankara University Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology
2
Republic of Turkey, Ministry of Agriculture and Forestry, Agriculture and Rural Development Support Institution
Abstract
Bu çalışmada, enjektabl preparatlarda vitamin D 3'ün stabilitesi için uygun saklama koşullarının belirlenmesi amaçlanmıştır. Enjekte edilebilir D vitamini preparatlarında vitamin D 3'ün farklı saklama koşulları altında zamana göre değişimleri belirlendi. Mühürsüz (analizin 0. gününde müstahzar mührü açılmış, diğer günlerde analizler için aynı müstahzar kullanılmıştır) ve mühürlü müstahzarlarda (her analiz gününde yeni müstahzar mührü açılarak analiz yapılmıştır) vitamin D analizleri yapılmıştır. 0, 7, 14, 28 ve 56. günlerde güncel ABD Farmakopesinin değiştirilmiş ve doğrulanmış bir yöntemiyle gerçekleştirilmiştir. D3 vitamini değişikliklerinin 4 °C'de saklama koşulları altında 25 °C'ye göre daha yüksek olduğu bulundu. D vitamini oranı 3Mühürsüz müstahzarlardaki değişiklikler, farklı saklama koşulları altındaki mühürlü müstahzarlara kıyasla önemli ölçüde arttı. Sonuç olarak, enjekte edilebilir vitamin preparatları açıldıktan sonra, oda sıcaklığında ve ışıksız çevre koşullarında uygun şekilde saklanabilmektedir.
Keywords
Vitamin D3,stability,storage conditions
How to Cite
BİLGİLİ, A., & ALAÇIK, O. . (2022). Levels of Vitamin D in Some Vitamin D Veterinary Preparations Kept in Different Storage Conditions. ISPEC Journal of Agricultural Sciences, 6(2), 195–201. https://doi.org/10.46291/ISPECJASvol6iss2id287
📄Anderson, J.S., Sunderland, R. 2002. Effect of extruder moisture and dryer processing temperature on vitamin C and E and astaxanthin stability. Aquaculture, 207: 137-149.
📄Arshad, A., Riasat, M., Mahmood, K. 2011. Drug storage conditions in different hospitals in Lahore. JPST, 3: 543-547.
📄Brunette, M.G., Chan, M., Ferriere, C., Roberts, K.D. 1978. Site of 1,25(OH)2 vitamin D3 synthesis in the kidney. Nature, 276(5685): 287‐289.
📄Combs, G.F. 1992. The vitamins fundamental aspects in nutrition and health. 4th Edition, p. 57-59.
📄Combs, G.F. 2008. Chemical and physiological properties of vitamins. In The Vitamins: Fundamental Aspects in Nutrition and Health, 3rd ed.; Elsevier Academic Press: Amsterdam, The Netherlands, pp. 503–514.
📄Dominick, B. 1980: The people’s guide to vitamins & minerals. Contemporary Books, Chicago.
📄Eder, K., Grundmann, S.M. 2022. Vitamin D in dairy cows: metabolism, status and functions in the immune system. Arch Anim Nutr, 1-33.
📄Gadient, M., Fenster, R. 1994. Stability of ascorbic acid and other vitamins in extruded fish feeds. Aquaculture, 124: 207-211.
📄Hajikolaei, M.R.H., Nouri, M., Amirabadi, S.H., Shariari, A., Constable, P.D. 2021. Effect of antepartum vitamin D3 (cholecalciferol) and postpartum oral calcium administration on serum total calcium concentration in Holstein cows fed an acidogenic diet in late gestation. Res Vet Sci, 136: 239-246.
📄Holick, M.F. 2006. Resurrection of vitamin D deficiency and rickets. J Clin Invest, 116: 2062-2072.
📄IADSA, 2013. The International Alliance of Dietary/Food Supplement Associations-Final Draft Shelf-life Recommendations for Supplements Guidelines for Manufacturer, p. 32. http://www.iadsa.org/publicatio ns/1474972849_Stability_Testing_for_Shelf_L. (Access: 07.06.2016).
📄Ismailova, A., White, J. H. 2022. Vitamin D, infections and immunity. Reviews in Endocrine and Metabolic Disorders, 1-13.
📄Kondepudi, N. 2016. Stability of vitamins in pharmaceutical preparations – A review. IJRASET 4: 499-503.
📄Kuong, K., Laillou, A., Chea, C., Chamnan, C., Berger, J., Wieringa, F.T. 2016: Stability of vitamin A, iron and zinc in fortified rice during strorage and its impact on future national standards and programs – case study in Cambodia. Nutrients, 8: 51.
📄Latic, N., Erben, R.G. 2021. FGF23 and vitamin D metabolism. JBMR Plus, 5(12): e10558.
📄Lewis, B. 2000. Update for nurse anesthetists refrigerated anesthesia related medications. AANA, 68: 265-268.
📄Rak, K., Bronkowska, M. 2018. Immunomodulatory effect of vitamin D and its potential role in the prevention and treatment of type 1 diabetes mellitus – a narrative review. Molecules, 24: 53.
📄Temova Rakuša, Ž., Pišlar, M., Kristl, A., Roškar, R. 2021. Comprehensive stability study of vitamin D3 in aqueous solutions and liquid commercialproducts. Pharmaceutics, 13(5): 617.
📄USP 32-NF 27 2009: In United States Pharmacopeia and National Formulary, The United States Pharmacopeial Convention, Inc: Rockville, MD.
📄Vernia, F., Valvano, M., Longo, S., Cesaro, N., Viscido, A., Latella, G. 2022. Vitamin D in inflammatory bowel diseases. mechanisms of action and therapeuticimplications, Nutrients, 14(2): 269.
📄Wang, T.J. 2016. Vitamin D and cardiovascular disease. Annu Rev Med, 67: 261-272.
📄Wang, J., Zhang, C., Zhang, T., Yan, L., Qiu, L., Yin, H., Ding, X., Bai, S., Zeng, Q., Mao, X., Zhang, K., Wu, C., Xuan, Y., Shan, Z. 2021. Dietary 25-hydroxyvitamin D improves intestinal health and microbiota of laying hens under high stocking density. Poult Sci, 100(7): 101132.
📄Yang, P., Ma, Y. 2021. Recent advances of vitamin D in immune, reproduction, performance for pig: a review. Anim Health Res Rev, 1-11.
📄Zhuge, Q., Klopfenstein, C.F. 1986. Factors affecting storage stability of vitamin A, riboflavin, and niacin in a broiler diet premix. Poult Sci, 65: 987-994.
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Onur ALAÇIK
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