Weeds significantly reduce the productivity and quality of wheat crop; therefore, exert negative impacts on wheat farming. Limited knowledge of weed distribution and the factors influencing their distribution is a major obstacle in weed control. This study investigated the taxonomy and distribution of weed species in the wheat fields of Yüksekova Basin and their relationship with soil properties. The prevalence and density of weed species in 80 wheat fields were recorded during 2020 and 2021. Soil samples were collected from each field at a depth of 0-20 cm for physicochemical soil analyses. A total of 87 weed taxa belonging to 18 families were identified, comprising 2 non-seed-producing, 18 monocotyledonous, and 67 dicotyledonous species. Additionally, the prevalence of cosmopolitan weeds adapted to different ecosystems was recorded from the study area. Canonical Correspondence Analysis (CCA) was conducted to demonstrate the impact of soil properties on the distribution of weeds. The findings indicated that soil texture, organic matter, soil reaction (pH) and nutrients content significantly influenced the distribution of weeds. The high spatial variation in soil properties led to significant spatial variation in the distributions of weed taxa. Considering this spatial variation is crucial for successful weed control, offering substantial savings in cost, labor, and time.