Aylin TAŞKAYA1 ,
Burcu ŞAHİN2 ,
Nur CEYHAN GÜVENSEN3 ,
Ramazan MAMMADOV2
1 Muğla Sıtkı Koçman University, Faculty of Sciences, Department of Biology, Muğla
2 Muğla Sıtkı Koçman University, Faculty of Sciences, Department of Molecular Biology and Genetics, Muğla
3 Ege University, Tire Kutsan Vocational School, Food Technology Program, İzmir
Abstract
Plants are widely used in the treatment of many diseases. This study evaluates for the first time the potential anticancer and antimicrobial activities of methanol extracts of leaves and flower parts of Verbascum napifolium, an endemic species distributed in the flora of Turkey. The antimicrobial activities were evaluated by the disc diffusion method and by determining the minimal inhibitory concentration (MIC). In all bacteria, flower methanol extract was found to be more sensitive. Escherichia coli was determined to be more sensitive to both extracts compared to all tested bacteria. These results suggest that V napifolium possess potential important anticancer and antimicrobial activities. The anticancer activities the effect of Verbascum napifolium flower and leaf methanol extracts on cell viability in CaCo-2 and L929 cell lines were determined by MTT assay. Flower methanol extract of Verbascum napifolium showed a better anticancer potential than the leaf methanol extract.
Keywords
Verbascum napifolium,anticancer activity,antimicrobial activity,CaCo-2,human cancer colon
How to Cite
TAŞKAYA, A. ., ŞAHİN, B. ., CEYHAN GÜVENSEN, N., & MAMMADOV, R. . (2023). A preliminary Study on Anticancer and Antimicrobial Potential of Methanolic Extracts of Verbascum napifolium. ISPEC Journal of Agricultural Sciences, 7(1), 135–145. https://doi.org/10.5281/zenodo.7749361
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Burcu ŞAHİN2