A preliminary Study on Anticancer and Antimicrobial Potential of Methanolic Extracts of Verbascum napifolium

Aylin  TAŞKAYA; Burcu  ŞAHİN; Nur CEYHAN GÜVENSEN; Ramazan  MAMMADOV

doi:10.5281/zenodo.7749361

Authors

Aylin TAŞKAYA Muğla Sıtkı Koçman University, Faculty of Sciences, Department of Biology, Muğla https://orcid.org/0000-0002-6221-3365
Burcu ŞAHİN Muğla Sıtkı Koçman University, Faculty of Sciences, Department of Molecular Biology and Genetics, Muğla https://orcid.org/0000-0003-0005-8539
Nur CEYHAN GÜVENSEN Ege University, Tire Kutsan Vocational School, Food Technology Program, İzmir https://orcid.org/0000-0001-8753-2664
Ramazan MAMMADOV Muğla Sıtkı Koçman University, Faculty of Sciences, Department of Molecular Biology and Genetics, Muğla https://orcid.org/0000-0003-2218-5336

DOI:

https://doi.org/10.5281/zenodo.7749361

Keywords:

Verbascum napifolium, anticancer activity, antimicrobial activity, CaCo-2, human cancer colon

Abstract

Plants are widely used in the treatment of many diseases. This study evaluates for the first time the potential anticancer and antimicrobial activities of methanol extracts of leaves and flower parts of Verbascum napifolium, an endemic species distributed in the flora of Turkey. The antimicrobial activities were evaluated by the disc diffusion method and by determining the minimal inhibitory concentration (MIC). In all bacteria, flower methanol extract was found to be more sensitive. Escherichia coli was determined to be more sensitive to both extracts compared to all tested bacteria. These results suggest that V napifolium possess potential important anticancer and antimicrobial activities. The anticancer activities the effect of Verbascum napifolium flower and leaf methanol extracts on cell viability in CaCo-2 and L929 cell lines were determined by MTT assay. Flower methanol extract of Verbascum napifolium showed a better anticancer potential than the leaf methanol extract.

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A preliminary Study on Anticancer and Antimicrobial Potential of Methanolic Extracts of Verbascum napifolium

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