A preliminary Study on Anticancer and Antimicrobial Potential of Methanolic Extracts of Verbascum napifolium

Alahmer, N. 2017. Verbascum cinsine ait bazı türlerin antimikrobiyal aktivitesinin incelenmesi. Yüksek lisans tezi, Kastamonu Üniversitesi Fen Bilimleri Enstitüsü, Kastamonu.

Angeloni, S., Zengin, G., Sinan, K.I., Ak, G., Maggi, F., Caprioli, G., Kaplan, A., Bahs, M., Çakılcıoğlu, U., Bouyahya, A., Jugreet, S., Mahomoodally, M.F., 2021. An insight into Verbascum bombyciferum extracts: different extraction methodologies, biological abilities and chemical profiles. Industrial Crops and Products, 161: 113201.

Atlas R. M., Parks L. C., Brown A. E. 1995. Laboratory Manual of Experimental Microbiology, Mosby-Year Book Inc., USA, 25.

Bakkalı, F., Averbeck, S., Averbeck, D., Idaomar, M., 2008. Biological effects of essential oils–a review. Food And Chemical Toxicology, 46(2): 446-475.

Başer, K.H.C., 2008. Sığırkuyruğu (Verbascum sp.). Bağbahçe. 61:22–23.

Bradshaw, L.J., 1992. Laboratory Microbiology, 4th ed. New York USA, Emeritus California State University, Saunders College Publishing, Fullerton.

Collins CM, Lyne PM. 1987. Microbiological Methods. Butterworths and Co. Ltd., London.

Cragg, G.M., Newman, D.J., 2005. Plants as a source of anti-cancer agents. Journal of Ethnopharmacology, 100(1-2): 72-79.

Donn, P., Barciela, P., Perez-Vazquez, A., Cassani, L., Simal-Gandara, J., Prieto, M.A., 2023. Bioactive Compounds of Verbascum sinuatum L.: Health Benefits and Potential as New Ingredients for Industrial Applications. Biomolecules, 13(3): 427.

Dulger, B., Dulger, G., 2018. Antibacterial Activity of Verbascum antinori. Konuralp Tıp Dergisi. 10(3): 395-398.

Dulger, B., Ugurlu, E., Aki, C., Suerdem, T. B., Camdeviren, A., Tazeler, G., 2005. Evaluation of antimicrobial activity of some endemic Verbascum., Sideritis., and Stachys. species from Turkey. Pharmaceutical biology, 43(3): 270-274.

Ghasemi, F., Rezaei, F., Araghi, A., Abouhosseini, T.M., 2015. Antimicrobial activity of aqueous-alcoholic extracts and the essential oil of Verbascum thapsus L. Jundishapur Journal of Natural Pharmaceutical Products, 10(3): 3.

Grigorov, M., Pavlović, D., Tadić, V., Nešić, I., Zlatković, B., 2022. Chemical composition of the ethanol extracts of Verbascum niveum flowers and leaves. Macedonian Pharmaceutical Bulletin, 68: 381-382.

Iliescu, I.A., Peter, S., Albert, I., Skalicka‐Woźniak, K., Miron, A., Luca, S.V., Wolfram, E., 2020. Verbascum nigrum: cytotoxicity evaluation in A431 epidermoid carcinoma cells and untargeted LC‐HR‐MS/MS metabolite profiling. Chemistry & Biodiversity, 17(12): e2000644.

Iqbal, J., Abbasi, B.A., Mahmood, T., Kanwal, S., Ali, B., Shah, S.A., Khalil, A.T., 2017. Plant-derived anticancer agents: A green anticancer approach. Asian Pacific Journal of Tropical Biomedicine, 7(12): 1129-1150.

Karaalp, C., Yurtman, A.N., Yavasoglu Karabay, N.Ü., 2009. Evaluation of antimicrobial properties of Achillea L. flower head extracts. Pharmaceutical Biology, 47(1): 86–91.

Kaya, G.İ., Somer, Ü.N., Konyalıoğlu, S., Yalçın, T.H., Yavaşoğlu Karabay, N.Ü., Sarıkaya, B., Önür, M.A., 2010. Antioxidant and antibacterial activities of Ranunculus marginatus var. trachycarpus and R. sprunerianus. Turkish Journal of Biology, 34: 139-146.

Khan, A.M., Qureshi, R.A., Gillani, S.A., Ullah, F., 2011. Antimicrobial activity of selected medicinal plants of Margalla Hills, Islamabad, Pakistan. Journal of Medicinal Plants Research, 5(18): 4665–4670.

Küçük, S., Özdemir, F., İşcan, G., Incesu, Z., 2016. Determination of Cytotoxic and Anticandidal Activities of Three Verbascum L. Species from Turkey: V-cheiranthifolium Boiss. var. asperulum (Boiss.) Murb. Monorg., V-pycnostachyum Boiss. & Heldr and V-orgyale Boiss. & Heldr. Turkish Journal of Pharmaceutical Sciences, 13(3).

Nofouzi, K., Mahmudi, R., Tahapour, K., Amini, E., Yousefi, K., 2016. Verbascum speciosum methanolic extract: Phytochemical components and antibacterial properties. Journal of Essential Oil Bearing Plants, 19(2): 499-505.

Scarpati, M.L., Delle Monache, F., 1963. Isolation from Verbascum sinuatum of two new glucosides, verbascoside and isoverbascoside. Annales de Chimie, 53: 356–367.

Senatore, F., Rigano, D., Formisano, C., Grassia, A., Basile, A., Sorbo, S., 2007. Phytogrowth-inhibitory and antibacterial activity of Verbascum sinuatum. Fitoterapia, 78(3): 244-247.

Sen-Utsukarcı, B., Dosler, S., Taşkın, T., Abudayyak, M., Özhan, G., Mat, A., 2018. Türkiye'deki beş Verbascum türünün antioksidan, antimikrobiyal, antibiyofilm ve sitotoksik aktivitelerinin değerlendirilmesi. Farmacia, 66: 1014-1020.

SPSS (n.d.) IBM SPSS Statistics for Windows, Version 22.0, Armonk, NY

Tatlı, İ.İ., Akdemir, Z.S., 2006. Cytotoxic activity on some Verbascum species growing in Turkey. Hacettepe University Journal of the Faculty of Pharmacy, (2): 77-86.

Tauchen, J., Doskocil, I., Caffi, C., Lulekal, E., Marsik, P., Havlik, J., ... & Kokoska, L., 2015. In vitro antioxidant and anti-proliferative activity of Ethiopian medicinal plant extracts. Industrial Crops and Products, 74: 671-679.

Turan, M., Mammadov, R., 2018. Antioxidant, antimicrobial, cytotoxic, larvicidal and anthelmintic activities and phenolic contents of Cyclamen alpinum. Pharmacology & Pharmacy, 9(04): 100.

Turker, A.U., Camper, N.D., 2002. Biological activity of common mullein, a medicinal plant. Journal of Ethnopharmacology, 82(2): 117–125.

Uğur, D., Güneş, H., Güneş, F., Mammadov, R., 2017. Cytotoxic Activities of Certain Medicinal Plants on Different Cancer Cell Lines. Turkish Journal of Pharmaceutical Sciences, 14(3): 222–230.

WHO 2013. WHO traditional medicine strategy: 2014–2023. Geneva: World Health Organization.

Yabalak, E., Ibrahim, F., Eliuz, E.A.E., Everest, A., Gizir, A.M., 2022. Evaluation of chemical composition, trace element content, antioxidant and antimicrobial activities of Verbascum pseudoholotrichum. Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 156(2): 313-322.