High-Sensitivity Cardiac Troponin (hs-cTnI and hs-cTnT) Levels in Dogs with Hepatozoon Canis

Ümit YAŞAR; Cemalettin  AYVAZOĞLU; Zehra Gül  YASAR; Şemistan  KIZILTEPE; Nilgün  AYDIN

doi:10.5281/zenodo.11336681

Yazarlar

Ümit YAŞAR Ardahan University, Nihat Delibalta Göle Vocational High School, Ardahan https://orcid.org/0000-0001-8110-7747
Cemalettin AYVAZOĞLU Igdır University, Tuzluca Vocational High School, Igdır https://orcid.org/0000-0003-2064-0657
Zehra Gül YASAR Ardahan University, Nihat Delibalta Göle Vocational High School, Ardahan https://orcid.org/0000-0001-6660-2643
Şemistan KIZILTEPE Igdır University, Tuzluca Vocational High School, Igdır https://orcid.org/0000-0003-3727-8893
Nilgün AYDIN Kafkas University, Faculty of Veterinary Medicine Department of Parasitology, Kars https://orcid.org/0000-0002-0571-7882

DOI:

https://doi.org/10.5281/zenodo.11336681

Anahtar Kelimeler:

Vector induced diseases, myocardial infarction, biomarkers, cardiac enzymes

Özet

The most common etiologic agent that causes canine hepatozoonosis is Hepatozoon canis (H. canis). High parasitemia is associated with symptoms of fever, anorexia, weight loss, anaemia, ocular discharge, and paralysis of the hind legs. The agent has also been reported to cause myocardial lesions. Troponins are considered the gold standard as they have high sensitivity and specificity for myocardial injury. The study consisted of a total of 27 dogs brought to Iğdır University Animal Hospital, 15 dogs diagnosed with H. canis infection by polymerase chain reaction analysis, and 12 healthy dogs. Of the examined dogs, 59.3% were female, and 40.7% were male. Of the dogs, 55.6% were 4 years old and under, and 44.4% were 5 years old and over. This study determined high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) levels in healthy dogs as 0.1262 and 0.1054 ng/mL, respectively. In dogs infected with H. canis, hs-cTnI and hs-cTnT levels were 0.4706 and 0.3056 ng/mL, respectively. In addition, there was a significant difference in serum Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and albumin levels in dogs infected with H.canis compared to the control. There was no significant increase in cholesterol and calcium levels. In conclusion, there was a significantly higher increase in hs-cTnT and hs-cTnI levels in dogs infected with H. canis. Considering that even the slightest change in troponin levels is important for prognosis, H. canis may have caused myocardial injury in dogs in our study. Besides, the relative increase in hs-cTnT and hs-cTnI detected in the healthy animal group may indicate various possible causes, such as low clearance and distant myocardial ischaemic events.

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High-Sensitivity Cardiac Troponin (hs-cTnI and hs-cTnT) Levels in Dogs with Hepatozoon Canis

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